Deild:  


Ólafur Eysteinn Sigurjónsson, Professor

School:School of Technology / Department of Engineering 
Phone:5435523   Mobile: 6949427 
Email:oesru.is 
Website:http://www.ru.is/starfsfolk/oes

Professor Sigurjonsson finished a B.Sc. dergree in molecular biolgy from the Univeristy of Iceland in 1998 and a M.Sc. degree in health sciences from the same university in 2001. Professor Sigurjonsson graduated with a PhD in stem cell biology and immunology from the Unversity of Oslo in 2006. Professor Sigurjonsson is the director of research and develpment and stem cell processing at the Blood bank, The Landspitali University Hospital and is an adjunct professor at the School of Helath Sciences University of Iceland. Professor Sigurjonsson is the co-founder and CSO of Platome biotechnolgies.  Professor Sigurjonson is the current president of the Scandinavians Soceity of biomaterials.
 
Professor Sigurjonsson´s research is within the field of regenertative medicine with a focus on developing methods for ex vivo culture of stem cells for clinical use and the use of tissue engineering and biomaterial sciences for bone development. He also does reasearch with the field of tranfusion medicine with the focus on understanding the formation of storage lesions in platelets and red blood cells and how pathogen redcution may affect those processes.
 
Publications (2012-2017)
 
1.    Óttar Rolfsson,Freyr Johannsson, Manuela Magnusdottir, Giuseppe Paglia, Ólafur E. Sigurjonsson, Aarash Bordbar, Sirus Palsson6, Sigurður Brynjólfsson, Sveinn Guðmundsson and Bernhard Palsson. Mannose and fructose metabolism in red cells during cold storage in SAGM.(In press in Transfusion 2017)

 2.     Aarash Bordbar, James T. Yurkovich, Giuseppe Paglia, Ottar Rolfsson, Ólafur E. Sigurjónsson, Bernhard O. Palsson. Elucidating metabolic physiology through network integration of quantitative time-course metabolomics. Sci Rep. 2017 Apr 7;7:46249. doi: 10.1038/srep46249.

 3.     Óttar Rolfsson, Ólafur E. Sigurjonsson, Manuela Magnusdottir, Freyr Johannsson, Giuseppe Paglia, Steinn Guðmundsson, Aarash Bordbar, Sirus Palsson, Sigurður Brynjólfsson, Sveinn Guðmundsson and Bernhard Palsson. Metabolomics comparison of red cells stored in four additive solutions reveals differences in citrate anticoagulant permeability and metabolism. Vox Sang. 2017 May;112(4):326-335.

 4.     Priyanka Sahariah,   Bergthóra S. Snorradóttir, Martha Á. Hjálmarsdóttir,   Ólafur E. Sigurjónsson and  Már Másson  Experimental design for determining quantitative structure activity relationship for antibacterial chitosan derivatives J. Mater. Chem. B, 2016,4, 4762-4770

 5.     Giuseppe Paglia, Angelo D’Alessandro, Óttar Rolfsson, Ólafur E. Sigurjónsson, Aarash Bordbar, Sirus Palsson, Travis Nemkov, Kirk C. Hansen, Sveinn Gudmundsson, Bernhard O. Palsson. BIOMARKERS DEFINING THE METABOLIC AGE OF RED BLOOD CELLS DURING COLD STORAGE (In Press Blood 2016)

 6.     Giuseppe Paglia, Ólafur E Sigurjónsson, Aarash Bordbar, Óttar Rolfsson, Manuela Magnusdottir, Sirus Palsson, Kristine Wichuk, Sveinn Gudmundsson, Bernhard O Palsson. Metabolic fate of adenine in red blood cells during storage in SAGM solution. Transfusion 10.1111/trf.13740, 2016

 7.     A. Bordbar, P.I. Johansson, G. Paglia, S.J. Harrison, K. Wichuk, M. Magnusdottir, S. Valgeirsdottir, M. Gybel-Brask, S.R. Ostrowski, S. Palsson, O. Rolfsson, O.E. Sigurjonsson, S. Gudmundsson, B.O. Palsson. Identified metabolomic signature for assessing red blood cell unit quality is associated with endothelial damage and clinical outcomes. Transfusion. 2016 Apr;56(4):852-62.

 8.     Nikhil N. Kulkarni, Hörður Ingi Gunnarsson, Zhiqian Yi, Steinunn Gudmundsdottir, Olafur E Sigurjonsson, Gudmundur H. Gudmundsson. Glucocorticoid dexamethasone down-regulates basal and vitamin D3 induced cathelicidin expression in human monocytes and bronchial epithelial cell line. Immunobiology. 2016 Feb;221(2):245-52.

 9.     Priyanka Sahariah, Kasper K. Sørensen, Martha Á. Hjálmarsdóttir, Olafur E. Sigurjonsson, Knud J. Jensen, Már Mássona and Mikkel B. Thygesenb Antimicrobial peptide shows enhanced activity and reduced toxicity upon grafting to chitosan polymers  Chem Commun (Camb). 2015 Jul 25;51(58):11611-4

 10.  Priyanka Sahariah, Berglind Eva Benediktssdóttir, Martha Hjálmarsdóttir, Ólafur Eysteinn Sigurjónsson, Mikkel Boas Thygesen, Már Mássona. Impact of chain length on the Antibacterial activity and Hemocompatibility of Quaternary N-alkyl chitosan derivatives Biomacromolecules. 2015 May 11;16(5):1449-60

 11.  Steinunn Guðmundsdottir, Ramona Lieder, Olafur E. Sigurjónsson and Petur H. Petersen. Chitosan leads to downregulation of YKL-40 and inflammasome activation in human macrophages. 2015 Aug;103(8):2778-85.

 12.  Giuseppe Paglia, Ólafur E. Sigurjónsson, Óttar Rolffson, Morten Bagge Hansen, Sveinn Guðmundsson, Bernhard Ø. Palsson.  Metabolomic Analysis of Platelet During Storage: A Comparison Between Aphaeresis and Buffy Coat Derived Platelet Concentrates. Transfusion. 2015 Feb;55(2):301-13.

 13.  Jonsdottir-Buch SM,  Sigurgrismdottir H, Lieder R and Sigurjonsson OE Expired pathogen inactivated platelet transfusion units support mesenchymal stroma cells in culture Cell Transplant. 2015;24(8):1545-54.

 14.  Joseph Lovecchio,  Sandra M. Jónsdóttir-Buch, Guðrún Kristín Einarsdóttir, Magnús Kjartan Gíslason, Gissur Örlygsson, Ólafur Eysteinn Sigurjónsson and Paolo Gargiulo. Assessment of Perfusion Bioreactors System Using μCT Technology and 3D Modeling Methods. Biomedizinische Technik/Biomedical Engineering Biomedizinische Technik 2014. 59(S1):302-305

 15.  Gislason MK, Procopio A; Orlygsson G, Sigurjonsson OE, Jonsson jr H, Gargiulo P. Finite element modelling of the distal radioulnar joint. Biomedizinische Technik/Biomedical Engineering. 2014. 59(s1):925-928

 16.  Giuseppe Paglia, Ólafur E. Sigurjónsson, Óttar Rolffson, Soley Valgeirsdottir, Morten Bagge Hansen, Sveinn Guðmundsson, Bernhard Ø. Palsson. Comprehensive metabolomic study of platelets reveals the expression of discrete metabolic phenotypes during storage. Transfusion. 2014 Nov;54(11):2911-23

 17.  Lieder R, Sigurjonsson OE.The Effect of Recombinant Human Interleukin-6 on Osteogenic Differentiation and YKL-40 Expression in Human, Bone Marrow-Derived Mesenchymal Stem Cells. Biores Open Access. 2014 Feb 1;3(1):29-34

 18.  Agnes Czeneka, Romane Blancharde, Alexander Dejacoc, Olafur E. Sigurjonsson, Gissur Orlygsson, Paolo Gargiuloa, Christian Hellmich.  Quantitative Intravoxel Analysis of microCT-scanned Resorbing Ceramic Biomaterials.  Journal of Materials Research. 2014. 29 (23) 2757-2772

 19.  Priyanka Sahariah, Vivek S. Gaware,  Ramona Lieder, Sigríður Jónsdóttir, Martha Hjálmarsdóttir, Olafur Eysteinn Sigurjonsson, Már Másson. Effect of Substituent, Degree of Acetylation and Positioning of the Cationic Charge on the Antibacterial Activity of Quaternary Chitosan Derivatives. Marine Drugs. 2014. 12(8), 4635-4658

 20.  Lieder R, Darai M, Orlygsson G, Sigurjonsson OE. Solution casting of chitosan membranes for in vitro evaluation of bioactivity. Biological procedures online 2014 Feb 1;3(1):29-34

 21.  Sigurgeirsson B, Thornorsteinsson H, Sigmundsdóttir S, Lieder R, Sveinsdóttir HS, Sigurjonsson OE, Halldórsson B, Karlsson K. Sleep-wake dynamics under extended light and extended dark conditions in adult zebrafish. Behav Brain Res. 2013 Nov 1;256:377

 22.  Jonsdottir-Buch SM, Lieder R, Sigurjonsson OE (2013) Platelet Lysates Produced from Expired Platelet Concentrates Support Growth and Osteogenic Differentiation of Mesenchymal Stem Cells. PLoS ONE 8(7): e68984. doi:10.1371/journal.pone.0068984

 23.  Einarsson JM, Bahrke S, Sigurdsson BT, Ng CH, Petersen PH, Sigurjonsson OE, Jonsson H Jr, Gislason J, Thormodsson FR, Peter MG. Partially acetylated chitooligosaccharides bind to YKL-40 and stimulate growth of human osteoarthritic chondrocytes. Biochem Biophys Res Commun. 2013 May 3;434(2):298-304.

 24.  Lieder R and Sigurjonsson OE. Stem cells and Tissue Engineering–The Ultimate Combo for Clinical Therapy? Drug Design 2013, S3. http://dx.doi.org/10.4172/2169-0138.S3-e001

 25.  Lieder R, Peteresen PH and Sigurjonsson OE. Endotoxins - the invisible companion in biomaterials research. Tissue engineering Part B: Reviews. 2013 May 3;434(2):298-304

 26.  Lieder R, Gaware VS, Thormodsson F, Einarsson JM, Ng CH, Gislason J, Masson M, Petersen PH, Sigurjonsson OE. Endotoxins affect bioactivity of chitosan derivatives in cultures of bone marrow-derived human mesenchymal stem cells. Acta Biomater. 2013 Jan;9(1):4771-8.

 27.  Paglia G, Palsson BO, Sigurjonsson OE. Systems biology of stored blood cells: Can it help to extend the expiration date? J Proteomics. 2012 Aug 28. pii: S1874-3919(12).

 28.  Halasi G, Søviknes AM, Sigurjonsson OE, Glover JC. Proliferation and recapitulation of developmental patterning associated with regulative regeneration of the spinal cord neural tube. Dev Biol. 2012 May 1;365(1):118-32.

 29.  Paglia G, Magnúsdóttir M, Thorlacius S, Sigurjónsson OE, Guðmundsson S, Palsson BØ, Thiele I. Intracellular metabolite profiling of platelets: evaluation of extraction processes and chromatographic strategies. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jun 1;898:111-20.

 30.  Lieder R, Darai M, Thor MB, Ng CH, Einarsson JM, Gudmundsson S, Helgason B, Gaware VS, Másson M, Gíslason J, Orlygsson G, Sigurjónsson OE. In vitro bioactivity of different degree of deacetylation chitosan, a potential coating material for titanium implants.  J Biomed Mater Res A. 2012  2012 Dec;100(12):3392-9

31.  Lieder R, Thormodsson F, Ng CH, Einarsson JM, Gislason J, Petersen PH, Sigurjonsson OE. Chitosan and Chitin Hexamers affect expansion and differentiation of mesenchymal stem cells differently. Int J Biol Macromol. 2012 Nov;51(4):675-80.

 32.  Lieder R, Reynisdottir SR, Thormodsson F, Chuen-How Ng, Einarsson JM, Gislason J, Bjornsson J, Gudmundsson S, Petersen PH and Sigurjonsson OE. Glucosamine increases the expression of YKL-40 and osteogenic marker genes in hMSC during osteogenic differentiation.  Natural Products and Bioprospecting Volume 2, Number 2 (2012), 87-91.  

RU teaching record

2019-1T-106-LIFVMolecular and Cell Biology
2019-1T-861-TISSTissue Engineering
2018-1T-106-LIFVMolecular and Cell Biology
2018-1T-861-TISSTissue Engineering
2017-3T-860-BIOMBiomechanics and Biomaterials
2017-1T-106-LIFVMolecular and Cell Biology
2017-1T-806-INDEIndependent Project
2017-1T-861-TISSTissue Engineering
More...

Honours and grants

 

Awards and membership
 
2007                 Awarded the Kings Gold medal by his majesty King Harald of Norway for my PhD thesis
 
2013-present    Board member of the Scandinavian society for biomaterials, holds the office of secretary 
 
2013                 Member of the Icelandic Academy of Sciences
 
2011-15             COST 1005 – NAMABIO (2011-2015). Management committee member.
 
2013-17            COST 1301 - NEWGEN New Generation Biomimetic and Customized Implants for Bone Engineering (2013-2017). Management committee member and co-proposer.
 
2014                 University of Iceland Applied Science Prize (3rd place)


Grants

 

The Landspitali-University Hospital Research foundation
Greining á frostþurkuðum blóðflögulýsötum úr útrunnum örveruóvirkjuðum blóðflögueiningum til notkunar í læknisfræðielgum tilgangi: 615.000 ISK
The Landspitali-University Hospital Research foundation
Notkun blóðflögulýsata úr útrunnum blóðflögueiningum til fjölgunar og beinmyndunar á mennskum miðlagsstofnfrumum: 510.000 ISK
The Landspitali-University Hospital Research foundation
Greining á metabólískum breytingum sem eiga sér stað við geymslu rauðfrumuþykkna: Leiðir til betri gæða rauðfrumuþykkna: 675.000 ISK
The Landspitali-University Hospital Research foundation
Nýstárlegt 3D frumuræktunarlíkan til in vitro greiningar á beinmyndun og beinummyndun: 425.000 ISK
Rannis infrastructure fund. Frumusorter; frumueinagrun með frumuflæðisjá: ~30.000.000 ISK
 
The Landspitali-University Hospital Research foundation
Noktun á EPD aðferðum til húðunar á títanígræðum með kítósani: Lífvirkni beinsérhæfingar. 370.000 ISK. Principal Investigator, Olafur E. Sigurjonsson.
 
Þróun og smíði á bioreactor kerfi til beinsérhæfingar og non-invasive aðferða til greiningar á beinmyndun in vitro. 345.000 ISK. Principal Investigator, Olafur E. Sigurjonsson.
 
Áhrif lýsata úr útrunnum blóðflögueiningum á vöxt, ónæmisbælingu og beinsérhæfingu miðlags-forverafruma sem sérhæfðar eru frá fósturstofnfrumum. 510.000 ISK. Principal Investigator, Olafur E. Sigurjonsson.
 
AVS: Aukið virði sjávarfangs.
Kítósanafleiður til að bæta lífvirkni ígræða: 3.800.000. Principal Investigator, Olafur E. Sigurjonsson.
 
Innviðasjóður Rannís:
Confocal smájá í Lífvísindasetur: 33.491.000 ISK
 
Student Innovation fund:
The potential use of lysates from expired pathogen inactivated platelets in mesenchymals tem cell culture: 360.000 ISK. Principal Investigator, Olafur E. Sigurjonsson.
 
The Landspitali-University Hospital Research foundation
Role of chitooligosacahrides in macrophage differentiation. 410.000 ISK, Principal Investigator, Olafur E. Sigurjonsson
 
The Landspitali-University Hospital Research foundation
The effect of platelet lysate manufactured from out-dated platelets on the expansion and differentiation of mesenchymal stem cells. 610.000 ISK, Principal Investigator, Olafur E. Sigurjonsson.
 
The Landspitali-University Hospital Research foundation
In vitro bioactivity of chitosan with different degree of deacetylation as apotential coating material for titanium implants. 825.000 ISK, Principal Investigator, Olafur E. Sigurjonsson.
 
The Landspitali-University Hospital Research foundation
The effect of overexpression of Dlg7 on differentiation of mouse embryonic stem cells. 370.000 ISK, Principal Investigator, Olafur E. Sigurjonsson.
 
Tækjasjóður Rannís:
Efnagreiningartæki fyrir örtækni- og líftæknilyf. 17.803.000 ISK
 
AVS research fund. In vitro bioactivity of different degree of deacetylation chitosan, a potential coating material for titanium implants. 4.300.000
 
Equipment Fund (Tækjasjóður)
Heresu Multifuge-X3-Bioshield 1000A, 1.100.000. Principal Investigator, Olafur E. Sigurjonsson.
 
The Landspitali-University Hospital Research foundation
The effect of platelet lysate manufactured from out-dated platelets on the expansion and differentiation of mesenchymal stem cells. 450.000 ISK, Principal Investigator, Olafur E. Sigurjonsson.
 
The Landspitali-University Hospital Research foundation
In vitro bioactivity of chitosan with different degree of deacetylation as apotential coating material for titanium implants. 920.000 ISK, Principal Investigator, Olafur E. Sigurjonsson.
 
Equipment Fund (Tækjasjóður)
StepOne Real Time PCR system from Applied Biosystem, 1.759.000. Principal Investigator, Olafur E. Sigurjonsson.
 
Multiskan Spectrum microplate spectrophotometer. 1.464.000. Principal Investigator, Olafur E. Sigurjonsson.
 
The Landspitali-University Hospital Research foundation
Role of Dlg7 in hematopoiesis.450.000 ISK, Principal Investigator, Olafur E. Sigurjonsson.
 
The Icelandic Research Fund (Rannsóknarsjóður)
Bioactive alloy implants (090007021). 15.000.000 ISK (over 3 years). Principal Investigator, Gissur Örlygsson
 
The Icelandic Research Fund (Rannsóknarsjóður)
Role of Dlg7 in hematopoiesis.13.600.000 ISK (over 3 years): grant number: 080438021, Principal Investigator, Olafur E. Sigurjonsson.
 
Technology Development Fund (Tækniþróunarsjóður): Influence of aminosugars on stem cell proliferation and differentiation Principal Investigator, Johannes Gislason. 30.000.000 ISK (over 3 years)
 
Equipment Fund (Tækjasjóður)
Heraeus Cytoperm 2 CO2/ O2 Incubator. 1.500.000 ISK, Principal Investigator, Olafur E. Sigurjonsson.
 
The Landspitali-University Hospital Research foundation
 Role of Dlg7 in hematopoiesis.660.000 ISK, Principal Investigator, Olafur E. Sigurjonsson.
Equipment Fund (Tækjasjóður)
Purchase of Leica DM2500 HCX microscope for transmitted light and fluorescence microscopy with digital photo equipment for stem cell research. 1.500.000 ISK
 
The Landspitali-University Hospital Research foundation
Gene expression profiling of bone marrow CD34+ hematopoietic stem cell derived megakaryocytes and megakaryocyte progenitor cells: A search for new genes that influence megakaryocyte development. 660. 000 ISK, Principal Investigator, Olafur E. Sigurjonsson.
 
Purchase of Leica DM2500 HCX microscope for transmitted light and fluorescence microscopy with digital photo equipment for stem cell research. 250.000 ISK, Principal Investigator, Olafur E. Sigurjonsson.
 
The Memorial Fund of Helga Jonsdottir and Sigurlidi Kristjansson Membership
2005: Neuronal differentiation of hematopoeitic stem cells. 13.000 $, Princepal Investigator, Olafur E. Sigurjonsson.

Publications

 

Book chapters
 
 
Lieder R, and Sigurjonsson OE. Chitosan as a coating material for titanium implants. (Requested book chapter for the book Chitin and Chitosan Derivatives: Advances in Drug Discovery and Developments, edited by Se-Kwon Kim). Published by CRP press. 2013
Journal papers                                                                                                 
 
1.     Gislason MK, Procopio A; Orlygsson G, Sigurjonsson OE, Jonsson jr H, Gargiulo P. Finite element modelling of the distal radioulnar joint. Biomedizinische Technik/Biomedical Engineering (in press 2014)
 
2.     Joseph Lovecchio, Sandra M. Jónsdóttir-Buch, Guðrún Kristín Einarsdóttir, Magnús Kjartan Gíslason, Gissur Örlygsson, Ólafur Eysteinn Sigurjónsson and Paolo Gargiulo. Assessment of Perfusion Bioreactors System Using μCT Technology and 3D Modeling Methods. Biomedizinische Technik/Biomedical Engineering (in press 2014)
 
3.     Giuseppe Paglia, Ólafur E. Sigurjónsson, Óttar Rolffson, Morten Bagge Hansen, Sveinn Guðmundsson, Bernhard Ø. Palsson.  Metabolomic Analysis of Platelet During Storage: A Comparison Between Aphaeresis and Buffy Coat Derived Platelet Concentrates.(2014 Transfusion- in press)
 
4.     Jonsdottir-Buch SM, Sigurgrismdottir H, Lieder R and Sigurjonsson OE Expired pathogen inactivated platelet transfusion units support mesenchymal stroma cells in culture (2014 Cell Transplantation – in press)
 
5.     Giuseppe Paglia, Ólafur E. Sigurjónsson, Óttar Rolffson, Soley Valgeirsdottir, Morten Bagge Hansen, Sveinn Guðmundsson, Bernhard Ø. Palsson. Comprehensive metabolomic study of platelets reveals the expression of discrete metabolic phenotypes during storage. (2014 Transfusion – in press)
 
6.     Lieder R, Sigurjonsson OE.The Effect of Recombinant Human Interleukin-6 on Osteogenic Differentiation and YKL-40 Expression in Human, Bone Marrow-Derived Mesenchymal Stem Cells. Biores Open Access. 2014 Feb 1;3(1):29-34
 
7.     Agnes Czeneka, Romane Blancharde, Alexander Dejacoc, Olafur E. Sigurjonsson, Gissur Orlygsson, Paolo Gargiuloa, Christian Hellmichc. Quantitative Intravoxel Analysis of microCT-scanned Resorbing Ceramic Biomaterials. (2014 – in press Journal of Materials Research)
 
8.     Priyanka Sahariah, Vivek S. Gaware, Ramona Lieder, Sigríður Jónsdóttir, Martha Hjálmarsdóttir, Olafur Eysteinn Sigurjonsson, Már Másson. Effect of Substituent, Degree of Acetylation and Positioning of the Cationic Charge on the Antibacterial Activity of Quaternary Chitosan Derivatives. Marine Drugs. 12(8), 4635-4658
 
9.     Lieder R, Darai M, Orlygsson G, Sigurjonsson OE. Solution casting of chitosan membranes for in vitro evaluation of bioactivity. Biological procedures online 2014 Feb 1;3(1):29-34
 
10. Sigurgeirsson B, Thornorsteinsson H, Sigmundsdóttir S, Lieder R, Sveinsdóttir HS, Sigurjonsson OE, Halldórsson B, Karlsson K. Sleep-wake dynamics under extended light and extended dark conditions in adult zebrafish. Behav Brain Res. 2013 Nov 1;256:377
 
11. Jonsdottir-Buch SM, Lieder R, Sigurjonsson OE (2013) Platelet Lysates Produced from Expired Platelet Concentrates Support Growth and Osteogenic Differentiation of Mesenchymal Stem Cells. PLoS ONE 8(7): e68984. doi:10.1371/journal.pone.0068984
 
12. Einarsson JM, Bahrke S, Sigurdsson BT, Ng CH, Petersen PH, Sigurjonsson OE, Jonsson H Jr, Gislason J, Thormodsson FR, Peter MG. Partially acetylated chitooligosaccharides bind to YKL-40 and stimulate growth of human osteoarthritic chondrocytes. Biochem Biophys Res Commun. 2013 May 3;434(2):298-304.
 
13. Lieder R and Sigurjonsson OE. Stem cells and Tissue Engineering–The Ultimate Combo for Clinical Therapy? Drug Design 2013, S3. http://dx.doi.org/10.4172/2169-0138.S3-e001
 
14. Lieder R, Peteresen PH and Sigurjonsson OE. Endotoxins - the invisible companion in biomaterials research. Tissue engineering Part B: Reviews. 2013 May 3;434(2):298-304
 
15. Lieder R, Gaware VS, Thormodsson F, Einarsson JM, Ng CH, Gislason J, Masson M, Petersen PH, Sigurjonsson OE. Endotoxins affect bioactivity of chitosan derivatives in cultures of bone marrow-derived human mesenchymal stem cells. Acta Biomater. 2013 Jan;9(1):4771-8.
 
16. Paglia G, Palsson BO, Sigurjonsson OE. Systems biology of stored blood cells: Can it help to extend the expiration date? J Proteomics. 2012 Aug 28. pii: S1874-3919(12).
 
17. Halasi G, Søviknes AM, Sigurjonsson OE, Glover JC. Proliferation and recapitulation of developmental patterning associated with regulative regeneration of the spinal cord neural tube. Dev Biol. 2012 May 1;365(1):118-32.
 
18. Paglia G, Magnúsdóttir M, Thorlacius S, Sigurjónsson OE, Guðmundsson S, Palsson BØ, Thiele I. Intracellular metabolite profiling of platelets: evaluation of extraction processes and chromatographic strategies. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jun 1;898:111-20.
 
19. Lieder R, Darai M, Thor MB, Ng CH, Einarsson JM, Gudmundsson S, Helgason B, Gaware VS, Másson M, Gíslason J, Orlygsson G, Sigurjónsson OE. In vitro bioactivity of different degree of deacetylation chitosan, a potential coating material for titanium implants. J Biomed Mater Res A. 2012 2012 Dec;100(12):3392-9
 
20. Lieder R, Thormodsson F, Ng CH, Einarsson JM, Gislason J, Petersen PH, Sigurjonsson OE. Chitosan and Chitin Hexamers affect expansion and differentiation of mesenchymal stem cells differently. Int J Biol Macromol. 2012 Nov;51(4):675-80.
 
21. Lieder R, Reynisdottir SR, Thormodsson F, Chuen-How Ng, Einarsson JM, Gislason J, Bjornsson J, Gudmundsson S, Petersen PH and Sigurjonsson OE. Glucosamine increases the expression of YKL-40 and osteogenic marker genes in hMSC during osteogenic differentiation. Natural Products and Bioprospecting Volume 2, Number 2 (2012), 87-91. 
 
22. Gudmundsson KO, Thorsteinsson L, Sigurjonsson OE, Keller JR, EgelandT, Gudmundsson S, RafnarT. Geen expression profiling of hematopoietic prognitor cells identifies Dlg7 as a potential stemcell gene. Stem Cell 2007 Jun; 25(6):1498-5106
 
23. Grogaard HK, Sigurjonsson OE, Brekke M, Klov E. Solberg KL, Lyberg T, Eriksen M, Egeland T, Ilebekk A. Cardiac accumulation of bone marrow mononuclear progenitor cells after intracoronary or intravenous injection in pigs subjected to acute myocardial infarction with subsequent reperfusion. (in press; Cardiovascular Revascularization. 8 (2007) 21-27.
 
24. Sigurjonsson OE, Perreault M-C, Egeland T, Glover JC. Human hematopoietic stem   cells produce functional neurons efficiently in regenerating chicken embryo spinal cord. Proc. Natl. Acad. Sci. U S A. 2005 Apr; 102(14):5227-5232.
 
25. Boquest AC, Shahdadfar A, Fronsdal K, Sigurjonsson OE, Tunheim SH, Collas P, Brinchmann JE. Isolation and Transcription Profiling of Purified Uncultured Human Stromal Stem Cells: Alteration of Gene Expression Following In Vitro Cell Culture.
Mol. Biol. Cell. 2005 Mar; 16(3): 1131-41.
 
26. Sigurjonsson OE, Gudmundsson KO, Haraldsdottir V, Rafnar T, Gudmundsson S. Flt3/Flk-2-Ligand in Combination With Thrombopoietin Delays Maturation and Decreases Apoptosis of Megakaryocyte Progenitor Cells Differentiated from Bone Marrow CD34+ cells in vitro. Stem Cells Dev. 2004 Apr; 13(2): 183-91.
 
27. Gudmundsson KO, Sigurjonsson OE, Gudmundsson S, Goldblatt D, Weemaes CMR, Haraldsson A. Increased expression of Interleukin-13 but not Interleukin-4 in CD4+ cells from patients with the hyper IgE syndrome. Clin Exp Immunol. 2002 Jun; 128(3):532-7
 
28. Sigurjonsson OE, Gudmundsson KO, Haraldsdottir V, Rafnar T, Gudmundsson S. Flt3/Flk-2-Ligand in Synergy with Thrombopoietin Delays Megakaryocyte Development and Increases the Numbers of Megakaryocyte Progenitor Cells in Serum-Free Cultures Initiated with CD34+ Cells. J.Hematotherapy and Stem Cell Research. 2002; 11: 389-400.
 
29. Sigurjonsson OE, Guðmundsson KO, Guðmundsson S. Mesenchymal stem cells. A review. Journal of the Icelandic Medical Association. 2001; 87: 627-632.

 

Invited speaker
 
Future of biomaterials. 04.12.2014. Seminar held at the department of biomaterials, University of Oslo. Topic: Expired and pathogen inactivated platelet concentrates for expansion
and differentiation of bone forming stem cells
 
The 9th International INTERCEPT meeting. 7th-9th of may 2014. Topic: Pathogen Inactivated Platelet Concentrates for expansion and Differentiation of Bone and Cartilage Forming Stem Cells
 
Symposium in molecular biology and connection with the annual meeting of the biology association. 7th march 2013. Topic: Expired and pathogen inactivated platelet concentrates for expansion
and differentiation of bone forming stem cells.
 
A conference on Parkinson’s disease. Hosted by the Icelandic Parkinson association. 5th October 2013. Topic: Stem cells in clinical therapy: Hype or Hope.
 
6th Annual meeting of the Scandinavian Society for Biomaterials, Hafjell, Norway, 13th-15th of March 2013. Topic: Endotoxins in Tissue engineering. Endotoxin – Your ever lurking companion in biomaterial research: Stem cells and Biomaterials.
 
The Icelandic Medical Association´s Annual Conference 2013 January 21st - 25th in HARPA - Reykjavik Concert Hall and Conference Centre. Topic: Repairing cartilage and bone tissue with stem cells.
 
Articles in conference proceedings
 
 
 
Quantitative intravoxel analysis of mu CT-scanned resorbing ceramic biomaterials
A Czenek, R Blanchard, A Dejaco, OE Sigurjonsson, G Orlygsson, P Gargiulo, C Hellmich.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE 8, 232-232. 2014
 
Assessment of perfusion bioreactors system using X-ray mu CT technology and 3D modeling methods
J Lovecchio, S Jonsdottir-Buch, GK Einarsdottir, G Orlygsson, OE Sigurjonsson, P Gargiulo.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE 8, 218-218. 2014
 
Jonsdottir-Buch SM, Sigurgrismdottir H and Sigurjonsson OE Expired pathogen inactivated platelet transfusion units support mesenchymal stroma cells in culture. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE 8,374-374. 2014
 
Jonsdottir-Buch SM, Sigurgrismdottir H and Sigurjonsson OE Expired pathogen inactivated platelet transfusion units support mesenchymal stroma cells in culture. Scandinavian society for biomaterial. 7th annual meeting Aarshus 26.-28. March 2014. (abstract published in European Cells and Materials)
 
Markéta Foley, Ramona Lieder, Joseph T. Foley, Gissur Örlygsson and Ólafur E. Sigurjónsson. Development of a Novel Electrophoretic Deposition (EPD) Method for Depositing Chitosan on Titanium Implants. European Society for biomaterials, Madrid 8.-12. Sept 2013.
 
Agnes Czenek, Giovana Lo Conte, Ramona Lieder, Gissur Örlygsson, Ólafur Eysteinn Sigurjónsson and Paolo Gargiulo. Monitoring Extracellular Matrix Mineralization Processes in Calcium Phosphate Scaffolds using X-ray µCT Technology and 3-D Modeling Methods. European Society for biomaterials, Madrid 8.-12. Sept 2013.
 
Paglia G, Sigurjónsson OE, Magnúsdóttir M, Thorlacius S, Guðmundsson S, Palsson BØ, Thiele I. Understanding alterations of platelets metabolism during in vitro storage by using UPLC-Q-TOF-MS strategy. ICMS 2012 Kyoto (International Conference Mass Spectrometry). 15.-21. September. Kyoto, Japan
 
Foley M, Lieder R, Foley JT, Orlygsson G and Sigurjonsson OE. In vitro bioactivity of chitosan attached to titanium constructs using novel electrophoretic deoposition method. Journal of Tissue engineering and Regenerative Medicine. Termis world congress. Volume 6, supplement 1; 29.P09. Vienna, Austria.
Lider R, Geware VG, Thormodsson F, Masson M, Peteresen PH, Sigurjonsson OE. Endotoxin- the real reason for the bioactivity in your in vitro cell assays? Termis world congress. Volume 6, supplement 1; 57.P35.Vienna, Austria.
 
Sigurgeirsson B, Sigmundsdottir S, Þorsteinsson H, Reynisdottir SR, Sigurjonsson OE, Halddorsson BV, Karlsson KÆ. Sleep-wake modulation of genetic expression in zebrafish. The Federation of European Neuroscience Societies (FNES), Forum of neurocience. 14.-18. July. Barcelona, Spain.
 
Paglia G, Magnúsdóttir M, Sigurjónsson OE , Thorlacius S, Guðmundsson S, Ines Thiele, Palsson BØ, Metabolomics of platelet concentrates: intracellular and extracellular changes occurring during platelet storage lesions. ASMS 2012 (Conference of American Society of Mass Spectrometry), 2.0.-24. May. Vancouver, Canada.
 
Ramona Lieder, Mariam Darai, Margret B Thor, C.-H. Ng, Jon M. Einarsson, Johannes Bjornsson, Benedikt Helgason6, Jóhannes Gíslason , Gissur Örlygsson and Ólafur E. Sigurjónsson. In vitro bioactivity of different degree of deacetylation chitosan as a potential coating material for titanium implants. Poster/ Oral presentation at Bone-Tec meeting, Hannover 2011
 
Ramona Lieder, Mariam Darai, C.-H. Ng, Jon M. Einarsso, Johannes Bjornsson, Benedikt Helgason6, Jóhannes Gíslason , Gissur Örlygsson and Ólafur E. Sigurjónsson.In vitro bioactivity of different degree of deacetylation chitosan as a potential coating material for titanium implants. Poster presentation for the TERMIS-EU Meeting 2010 13th to 17th June.
 
Aminosugars in Regenerative Medicine: Chitin Derivative as Coating Material for Titanium Implants
M Darai, G Orlygsson, J Gislason, CH Ng, JM Einarsson, OE Sigurjonsson and Brynjolfsson. Tissue engineering part A 15 (5), O7-O7
 
Níels Árni Árnsason, Kristbjorin Orri Gudmundsson, Leifur Throsteinssin, Jonathan R. Keller and Olafur E. Sigurjonsson. Dlg7 in heamtopoietic development. The European Summer School on Stem Cells & Regenerative Medicine. 2009.
 
Gabor Halasi , Ólafur E. Sigurjónsson, Torstein Egeland, Joel C. Glover. Appropriate dorsal ventral genetic patterning following regulative regeneration of chicken embryo spinal cord. Hungarian society for neuroscience. 2007.
Sigurjonsson OE, Egeland T, Glover JC. Human hematopoietic stem cells produce neurons efficiently in regenerating chicken embryo spinal cord (Keystone, Molecular Regulation of Stem Cells (B3) February 10 - 15, 2005)
 
Sigurjonsson OE, Perreault M-C, Egeland T, Glover JC.Evidence for production of neurons by human CD34+ bone marrow cells implanted into the regenerating chicken embryo spinal (Society for Neuroscience, Poster, 2005)
 
Sigurjonsson OE, Egeland T, Glover JC. Human hematopoietic stem cells produce neurons efficiently in regenerating chicken embryo spinal cord (Society for Neuroscience, Poster, 2004). The abstract was chosen among 600 abstracts (out of 16.000) to appear in the meetings pressbook.