Systems Biology

Námsgrein	T-765-SYBI
Önn	1
Einingar	8
Skylda	Nei

Ár	1. ár
Önn	Vorönn/Spring 2024
Stig námsgreinar	Grunnnám, sérhæft námskeið / Framhaldsnám, grunnnámskeið
Tegund námskeiðs	Valnámskeið
Undanfarar	T-101-MATL, Forritun í Matlab T-101-STA1, Stærðfræði I T-201-STA2, Stærðfræði II T-211-LINA, Línuleg algebra T-301-MATH, Stærðfræði III
Skipulag	Ekkert skráð skipulag.
Kennari	Eliahu August
Lýsing
Without a quantitative framework to describe networks of interacting components, the functioning of cellular networks cannot be resolved. This course provides the foundation to a quantitative approach to molecular biology by means of mechanistic mathematical models. Throughout the course, we will develop an understanding of the biology of important systems and related biological questions, where mathematics can help in providing answers. We will see how to develop a mathematical model that represents relevant biological processes and use mathematical theories and computational methods to obtain predictions from the model. A final step will be to check that those predictions provide an answer to the biological question. The course topics are as follows: - Nonlinear dynamical systems (ODEs), modelling, and simulation - Analysing ODEs: equilibrium points, limit cycles, stability, and bifurcations - Chemical Reaction Network Theory - Transcription Networks and network motives: Feedback, feedforward, and autoregulation - Enzyme Kinetics - Population Dynamics, models of epidemics
Námsmarkmið
On completion of the course, you should be able to: - formulate and numerically solve mathematical models of different biological processes, - use techniques from nonlinear dynamical systems theory to analyse those models, - describe important biological, physiological, and ecological processes and their respective models, - place the course’s approaches within the wider context of, e.g., drug discovery and chancer therapy.
Námsmat
Presentation, project, final exam.
Lesefni
Ekkert skráð lesefni.
Kennsluaðferðir
Taught for 12 weeks. Lectures, exercises, paper presentations, project.
Tungumál	Enska